1606. Dual Trajectories of Antiretroviral Therapy Adherence and Polypharmacy in Women with HIV in the United Sate

Abstract

Abstract Background Polypharmacy using five or more medications with antiretroviral therapy (ART) may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to ART and polypharmacy. Methods We included women with HIV (aged >18 years) enrolled in the Women's Interagency HIV Study in the United States from 2014-2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and dual GBTM to identify the interrelationship between adherence and polypharmacy. Results Overall, 1538 were eligible (median age of 49 years). GBTM revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group. Conclusion The joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories. Future research should consider examining the interrelationship between both variables using objective measures of adherence. Disclosures Jessica Haberer, MD, MS, Merck: Advisor/Consultant