Abstract

Prior data suggest that men with good erectile function (EF) early after radical prostatectomy (RP) can worsen their EF over the first 6 months postoperatively. We aimed to determine the prevalence and predictors of worsening EF after RP. 1,655 men who (i) underwent RP (ii) completed IIEF EF domain (EFD) pre-RP and (iii) serially post-RP constituted the population. Functional erections (FE) were defined as EFD score ≥24. We analyzed factors predicting FE at 3 months post-RP as well as factors predicting a decrease in FE between 3-6 months, defined as a two point drop or more in EFD score. Multivariable logistic regression (MVA) models were used with the following predictors: patient age at RP, baseline and 3-month EFD scores, PDE5i use at 3m (always vs other), diabetes, hypertension, hyperlipidemia, sleep apnea, cigarette smoking status (never vs current vs former), and nerve-sparing status (NSS; none vs unilateral vs bilateral).

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