Abstract
Hair follicle stem cells (HFSCs) are multipotent epithelial stem cells that undergo cyclical bouts of growth and rest. They reside in a niche called the bulge and aid in wound healing, regulate the hair cycle, and produce new hair shafts every round of the hair cycle. The transcription factor, cyclic AMP (cAMP)-responsive element binding protein (CREB) plays a role in cell proliferation, differentiation, and is involved in the G-protein-coupled receptor (GPCR) signaling pathway. In vivo experiments on murine dorsal skin revealed that the phosphorylated, active form of CREB can be induced in the bulge upon topical treatment with a variety of compounds that facilitate downstream CREB activity such as cAMP, forskolin, and phosphodiesterase inhibitors.
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