Abstract
Several heterocyclic molecular frameworks have been regarded as privileged structure in the field of medicinal chemistry. These privileged structure or scaffolds or moieties display wide range of biological activities. Therefore, synthesis of the heterocycles having these privileged structures is an essential part in the drug discovery and development process. In this study, an attempt has been made to review and summarize recent developments in the synthetic strategies of 1,5-benzothiazepine and their derivatives. Various recent synthetic strategies including general, one-pot, green, ionic liquid, enantioselective synthesis and asymmetric hydrogenation of the 1,5-benzothiazepine are reviewed and summarized. To the best of our knowledge, the present manuscript is the complete compilation on the recent developments in the synthetic strategies of the 1,5-benzothiazepines.
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