Abstract
Neuropathy and nephropathy are two secondary complications often seen in the IDDM patient. Aim of this study was to look for early signs of these complications in young diabetics and whether there was a correlation with age, duration and control of diabetes (HbA1). Furthermore we investigated if there was a correlation between neurological and nephrological findings. So far 18 asymptomatic IDDM patients (age mean +/- SD: 12.4 +/- 2.5 years, 13 boys - 7 girls, duration of disease 0.4 - 9.2 years) and 11 controls (11.7 +/- 1,9 years, 7 girls - 4 boys) were neurophysiologically examined by means of EMG, nerve-conduction velocity studies and somato-sensory evoked-potentials (SSEP). 24-hour urine samples were collected and examined for microalbuminuria and b-glucosaminidase. Preliminary results show significant differences in nerve conduction velocities and indications suggesting early central nervous involvement in the patient-group. However no clear correlation between these findings and HbA1, age and duration of disease was found although higher HbA1 levels were found in those patients with greater number of nerves involved. We found no correlation between the neurophysiological findings and the degree of microalbuminuria and the urinary levels of b-glucosaminidase.
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