Abstract
Background: There have been many studies for epithelial-to-mesenchymal transition (EMT) of the cancer, especially focused on the important transcriptional factors. Recently epigenetic mechanisms, including histone modification have been comprehensively studied for establishing the role on the prohibiting metastasis of cancer cell. The objective of presenting study is to investigate the epigenetic role of histone lysine methylation/demethylation on the regulating expression of the transcriptional factors of EMT in lung cancer and brain metastasis.
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