Abstract
We compared the effects of isovolumetric hemodilution (HD) with saline (n=8) and human serum (n=8) on venous hematocrit (Hct), plasma volume (PV, Evans Blue), blood volume (BV), and total plasma protein (TPP) in 16 term neonates with venous Hct>0.65. The exchange volume was 80 ml/kg × (Hct-55)/Hct, aiming at Hct 0.55. Results (±SD)Isovolumetric HD with saline resulted in a smaller (p<0.05) decrease in Hct than HD with serum and was not associated with an isovolemic substitution of withdrawn blood, out with a decrease of BV at the end and 4h after HD, because saline left the intravascular space already during HD.Conclusion: Rapid loss from the intravascular volume and the decrease of blood volume make saline less effective for HD in neonatal polycythemia and possibly for volume substitution in general.
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