Abstract

Germline genetic testing affords multiple opportunities for women with breast cancer relating to (i) treatment of a current breast cancer, (ii) management of risk of future cancers, and (iii) identification of at-risk family members. In the UK, testing remains restricted to individuals at highest a-priori risk of carrying a pathogenic variant (<20% of women diagnosed with a breast cancer). The main barrier to expanding testing is a shortage of clinical resource due to current requirements to complete complex eligibility assessments, 1:1 pre-test genetic counselling, and pathway management.

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