1561P Anemia and iron deficiency (ID) in association with tissue iron regulators - Hepcidin, ferroportin and ZIP14 expression in patients with pancreatic cancer (PC)

Abstract

Anemia and iron deficiency (ID) are common findings in cancer patients (pts), resulting in impaired physical function and fatigue. Hepcidin (HEP) and ferroportin (FPN) are known iron regulators. HEP exerts its regulatory function by binding to the iron exporter FPN. ZIP14 membrane transporter controls influx of nontransferrin-bound iron (NTBI) into cell. These iron regulators may be produced locally by the tumor. The aim of the study was to evaluate the prevalence of anemia and ID with assessment of tissue iron regulators - HEP, FPN and ZIP14.