Abstract
Background: TGF-β1 and COX-2 overexpression plays key role in tumorigenesis of nonmelanoma skin cancer. STP705 is a combination of TGF-β1/COX-2 siRNAs formulated in histidine-lysine copolymer nanoparticle delivery system. We studied the effect of STP705 on the growth of human squamous carcinoma (A431) xenograft tumors in nude mice and viability of human cutaneous squamous carcinoma (HSC-1) cells.
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