15524 Ten of TEN and counting: The story of Toxic Epidermal Necrolysis (TEN) at the University of New Mexico from 2017 to 2018

Abstract

Stevens-Johnson syndrome (SJS) and TEN are rare, acute, life-threatening mucocutaneous diseases often due to drug-induced immune-mediated epidermal necrosis. Associated symptoms include skin pain, fever, anxiety, and asthenia. Rashes initially appear benign but progress rapidly and unpredictably. Commonly affected populations include women, slow-acetylator genotypes, immunocompromised, and those treated with concurrent anticonvulsant and radiotherapy. High risk HLA types include B1502 in Asian/East Indians (carbamazepine) and B5801 in Han Chinese (allopurinol).