Abstract
Herpes simplex virus infects a broad range of mammalian cells, including epithelial cells, lymphocytes, and postmitotic neurons. HSV-1 entry into cells is initiated by the binding of viral envelope glycoprotein D (gD) to one of three known HSV entry receptors, nectin-1/HveC, HVEM/HveA, and 3-O-sulfotransferase-modified heparan sulfate. Interaction of gD with these entry receptors is believed to cause a conformational change in gD, enabling it to interact with other envelope components which ultimately results in fusion of the viral envelope with the cell membrane.
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