Abstract
Pazopanib (PAZ) is an angiogenesis inhibitor approved for the treatment of renal cell carcinoma (RCC) and soft tissue sarcoma (STS). A relationship was reported between PAZ trough concentration (Cmin) and progression free survival (PFS) in RCC (Suttle A.B. 2015; Verheijen R.B. 2017). However, information on the exposure-efficacy relationship in sarcoma remains sparse. A PAZ Cmin threshold of 27 mg/L was determined in an exploratory study (Bellesoeur A. 2017).
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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