Year-end Sale % OFF 
Abstract
We studied steroid cell (ovary, testis, placenta) (SCA) and adrenal (AA) antibodies in 311 serum samples collected from the Finnish whole-population-based series of 47 patients with APECED during 1.3-13 (mean 7.3) years. 15 patients had no antibodies. 3 patients had AA alone, 28 had AA+SCA and 1 patient had SCA alone. AA and/or SCA were observed in 30/34 patients with adrenocortical failure (A) and in 4/13 without A (p=0.0002), in 13/13 females with ovarian failure (O) and in 7/13 females without O (P= 0.01). A was observed to develop in 12/25 patients. AA or SCA appeared in 11/12 of them in contrast to 4/13 of patients maintaining normal adrenal function (p=0.003). O was observed to develop in 10/23 patients. In 10/10 of them AA and SCA appeared in contrast to 7/13 females maintaining normal ovarian function (p=0.02). SCA were detected in 29/47 patients, in contrast to 6/7 patients of Elder (JCEM 1981:52:1137) who all had a multicomponent disease. 5/16 of our patients with no or 1 endocrinopathy, 8/13 of those with 2 and 16/18 of those with 3 or more endocrinopathies had SCA. Thus SCA were commoner in patients with multicomponent endocrinopathy (p=0.003).
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
