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Abstract

Objectives This study aimed to assess whether changes in blood pressure during pregnancy is associated with hypertension in later life in Japanese women with or without pregnancy induced hypertension (PIH). Methods The eligible study population consisted of 1100 women who were ⩾ 40 years old, underwent a health check-up at a periodic health examination facility in Aichi, Japan, between January 2012 and December 2013, and had experience giving birth. Questionnaires were sent to potential participants and they were encouraged to provide their Maternal and Child Health Handbooks. We recruited women with a history of PIH (PIH group) and of uncomplicated pregnancies at delivery (control group). Information obtained from the Maternal and Child Health Handbooks. Participants were divided into five periods of whole gestation period and the average maximum value of systolic blood pressure calculated in each period. We assessed the association between changes in average systolic blood pressures during pregnancy and hypertension in later life in Japanese women with or without PIH. Results The odds ratios (OR) of antihypertensive medication use for the PIH group in later life was 4.31 (95%CI, 2.69–6.88) by average blood pressure 10 mmHg rise during pregnancy, OR for the control group was 1.38 (95%CI, 1.01–1.90). Conclusions Our findings suggest that high blood pressure during pregnancy in women without a history of PIH is high risk of hypertension in later life. Disclosures C. Kimura: None. K. Watanabe: None. A. Iwasaki: None. T. Mori: None. H. Matsushita: None. K. Shinohara: None. A. Wakatsuki: None.