Abstract
Skin provides critical barrier properties that enable terrestrial life. Myriad research has focused on the “water barrier” to transepidermal water loss (TEWL) despite there being a multitude of skin barrier properties. We asked what other barrier properties may have been overlooked and compiled data demonstrating the “electrolyte barrier” to be of clinical relevance. Specifically, data summarized within this review demonstrate that the percutaneous egression of ions, or the outward diffusion of ions through skin, is a useful marker of assessing skin barrier function; experimental damage to skin in vivo or ex vivo frequently induced increased ion flux rates through the epidermis, in addition to expected increases to TEWL values.
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