Abstract
Dedifferentiated liposarcomas (DDLPS) are one of the most frequent sarcoma subtypes, characterized by the coexistence of one low-grade, adipocytic, well-differentiated (WD) component and one high-grade, undifferentiated (DD) component. The molecular mechanisms determining the existence of these two distinct cell populations are poorly understood. We performed a multi-omics characterization of DDLPS to decipher the molecular and micro environmental characteristics of WD and DD components.
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