151 Poster - Role of miR-21 in chemotherapeutic drug resistance of oral squamous cell carcinoma

Abstract

Background: Head and neck carcinoma spreads malignancies tumors arising from the epithelium or squamous covering the upper aerodigestive tract including oral that metastasize to other organs. The oral squamous cell carcinoma primarily addressing Head and neck carcinoma cancer that could affect the majority of older people with approximately 650,000 new cases per year. The consumption of alcohol and tobacco might be the prime cause of OSCC risk. But the recurrence or relapse of the malignancies is the major obstacle of the convention chemotherapeutic drug like paclitaxel or carboplatin. We know the circulating miRNAs is noted as the potential biomarkers of OSCC but their role in drug resistance is yet to reveal. In the present study, an attempt made to find the expression of miR-21 in serum/ whole blood of relapse OSCC (rOSCC) and newly identified OSCC (nOSCC) (N = 40). The expression of miR-21 was evaluated in relation to different demographical and clinicopathological features aiming to identify correlation with relapse and their cancer clinical stages (perineural invasion and N-stage).