15099 Association of psoriasis with inflammatory bowel disease: A retrospective study

Abstract

Psoriasis is a chronic inflammatory disease characterized by localized or widespread silvery, scaly, and erythematous plaques distributed symmetrically. Several studies have demonstrated the association of psoriasis with inflammatory bowel disease (IBD). IBD comprises two principle phenotypes, Crohn disease (CD) and ulcerative colitis (UC). The prevalence and relative risk of IBD in psoriatic patients and in those with psoriatic arthritis (PsA) are higher than in the general population. This study aims to determine IBD prevalence in patients with psoriasis while correlating IBD with psoriasis phenotype. A retrospective cohort study was performed reviewing charts at the University of Puerto Rico Dermatology Clinics from January 2016 to March 2019. The following were assessed: demographics, past medical history, age at IBD diagnosis, treatment, and PsA. Total number of patients with psoriasis was 719 of which 9 (1.12%) had IBD with a mean age at diagnosis of thirty; 33% (3) had Crohn disease, and 67% (6) had ulcerative colitis. PsA was observed in 33% of patients with concomitant IBD and psoriasis. Prevalence of PsA, rheumatoid arthritis, diabetes mellitus, and hypercholesterolemia did not differ between IBD and non-IBD groups. Our study showed that 67% of patients who developed IBD presented with mild psoriasis, whereas 62% of patients with psoriasis without IBD presented with severe psoriasis. Biologic treatment for psoriasis correlated with fewer IBD symptoms. Our study compares to other studies and makes us consider implementing biologic treatment for psoriasis earlier in the course to prevent other inflammatory diseases such as IBD.