1506 PREVALENCE OF OVERACTIVE BLADDER (OAB) AND ASSOCIATED RISK FACTORS IN 1,359 PATIENTS WITH TYPE 2 DIABETES

Abstract

INTRODUCTION AND OBJECTIVES: The aim of the study was to evaluate the prevalence of overactive bladder (OAB, dry and wet) and associated risk factors of OAB wet (with incontinence) in type 2 diabetes. METHODS: A self administered questionnaire containing overactive bladder symptom score (OABSS, 0–15, indicating increasing severity of symptoms) was obtained from subjects with type 2 diabetes at a dedicated diabetic center. The association of age, gender, duration of diabetes, body mass index (BMI), waist circumference, glycated hemoglobin (Hb A1c) level, high sensitive CRP level, and diabetes associated complications to risk of OAB and OAB wet was evaluated. RESULTS: Of 1,359 consecutive subjects, 22.5% reported having OAB with 11.7% reporting OAB dry and 10.8% with OAB wet. There were statistically significant difference of symptom severity among no OAB, OAB dry, and OAB wet (OABSS 2.5 / 1.4, 5.9 / 1.6 and 8.9 / 2.6, respectively). The prevalence of OAB and OAB wet were 2.4 fold and 4.2 fold greater, respectively, in patients with DM duration 10 years and age 50 years. Age, male gender, and age, waist circumference were independent risk factors for OAB and OAB wet, respectively, after multivariate analysis. Hb A1c and CRP levels were similar between DM patients with and without OAB. CONCLUSIONS: In a dedicated diabetic center where all patients were screened, 22.5% has OAB and 48.0 % of OAB patients had incontinence. These findings can help guide collaboration between urologists and diabetologists to work toward developing screening for and early treatment of urologic complications in higher risk patients.