1506-P: Nonalcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes Mellitus (T2DM) Patients in India: A Real-World Perspective

Abstract

Objective: NAFLD is highly prevalent in T2 DM patients. In addition to diabetes, factors like age (> 45 years), obesity (body mass index > 30 kg/m2), dyslipidemia, hypertriglyceridemia, hypertension and poor control of diabetes contribute to higher risk of having NAFLD. Therefore, the study was designed to evaluate the profile of T2DM patients with NAFLD in India alongwith determining high risk factors for having NAFLD. Methodology: Ultrasonographic (USG) records (1985) of patients with available liver function test (LFT) reports were analyzed after excluding alcoholic liver disease (ALD) and other known causes of liver injury. Various clinical and diagnostic parameters were assessed. Univariate and multivariate logistic regression was used to determine significant risk factors (P value <0.05). Results: Out of 1985 patients, 72.24% patients had NAFLD. Most were males (65%), >40 years (82.99%) and obese/overweight (92%). Most had normal SGOT (89.33%) and SGPT (74%) levels. The ratio of SGOT/SGPT was less than 1 in 77.20% patients. Most (51.62%) patients had poor control of diabetes (HbA1c >7.5%). Dyslipidemia and hypertriglyceridemia were seen in 80% and 48.16% patients. On univariate logistic regression analysis, age (P<0.001), uric acid (P<0.05), SGOT (P<0.001), SGPT (P<0.001), triglycerides (P<0.001), HDL (P<0.001) and LDL (P<0.001) levels were significantly associated. On multivariate analysis, only HDL (P<0.001), SGOT (P<0.001), SGPT (P<0.001) and SGOT/SGPT ratio (P<0.001) were significantly associated. A predictive algorithm using the above was designed and validated. Conclusion: NAFLD was seen to be highly prevalent in diabetes patients in India. Most of these patients had normal LFT values which highlight the need for routine screening and management of these patients, especially those with high risk factors. Disclosure V. Singh: None. M. Singh: None. H. Patidar: None.