15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality.

Abstract

LettersJune 202315-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and MortalityHermann Brenner, MD, MPH, Thomas Heisser, PhD, Rafael Cardoso, PhD, Michael Hoffmeister, PhD, MScHermann Brenner, MD, MPHDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, GermanySearch for more papers by this author, Thomas Heisser, PhDDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, GermanySearch for more papers by this author, Rafael Cardoso, PhDDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, GermanySearch for more papers by this author, Michael Hoffmeister, PhD, MScDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, GermanySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L23-0024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Juul and colleagues (1) provide the most comprehensive analysis to date on the effects of offering flexible sigmoidoscopy on colorectal cancer (CRC) incidence and mortality. Their pooled analysis of 15-year follow-up data from 4 large randomized controlled trials convincingly shows substantial and sustained reduction in both CRC cases and deaths. In intention-to-screen analyses, incidence reduction of any CRC and distal CRC was reported as 21% and 32%, respectively.However, the reported reduction refers to detected CRC cases rather than truly incident ones. The CRC detection rate was higher in the intervention group than in the usual care ...