15 ROLE OF NEUROPEPTIDE Y GEN RS 16147 POLIMORFISM AS A RISK FACTOR FOR HYPERTENSION

Abstract

Background: According to World Health Organization (WHO), hypertension has been a medical problem that associated with 7.5 millions (12.8 percents) death in wide world. Neuropeptide Y (NPY) is the most often found neurotransmitter in nervous system, comes from expression of NPY gen rs16147, has effect in symphatetic tonus enhancement result in increasing blood pressure (BP). Objective: To determine role of NPY Gen RS 16147 Polimorfism as a risk factor of hypertension. Method: Analytic study with case control design to determine relationship between NPY Gen RS 16147 Polimorfism: C-399T and BP with Chi Square test. Population consist of 100 sample (50 male,50 female) with consecutive sampling. Sample taken from venous blood, analyzed using Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) method. p value <0,05 means statistically significant. Result: Study enrolled subject with median age 51,5 (22—83) years (26 normotension, 74 hypertension), subject with alel “C” NPY RS 16147 genotype has abnormal BP, while subject with non alel “C” NPY RS 16147 (TT genotype) has both normal and abnormal BP, (p: 0.017). Average systolic blood pressure (SBP) in non alel “C” NPY RS 16147 genotype is 139,05±21,42 mmHg, while average SBP in alel “C” genotipe NPY RS 16147 genotype is 151,32±22,26 mmHg. Conclusion: Neuropeptide Y Gen RS 16147 polimorfism is a risk factor for hypertension. The presence of alel “C” in NPY RS16147 related to high BP significantly.