Abstract
Rabbits are used as a tool to demonstrate interferon-inducing capacity of various nonviral inducers. Cultures of rabbit cells are widely employed for studies on the regulation of interferon induction and attempts are made to purify rabbit interferon. Rabbits can be utilized to analyze such activities as the effect of interferon on corneal xenograft or experimental keratitis produced by herpes simplex virus. Secondary rabbit kidney cell (RKC) cultures are prepared from cells obtained by trypsinization of primary cultures, using the same growth medium as for primary cultures. An alternative way to enhance the yield of interferon is through UV irradiation of RK13 cells prior to treatment with poly(I) . poly(C). High titers of interferon can be produced in the serum of rabbits following intravenous injection of various inducers. Poly(I) . poly(C) can also be used for the production of high-titered interferon preparations.
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