14P Identification of age-associated genes as prognostic factors in non-small cell lung cancer

Abstract

The inevitability of a time-dependent decline in physiological organ performance as we age is a major risk factor for cancer development. As a result, the population is changing, with a growing number of people at risk of acquiring cancer. Cell senescence is one of the hallmarks where cancer and aging are fundamentally different as accumulating DNA damage usually will cause an upregulation of cell cycle inhibitors leading to senescence or apoptosis while malignant cells avoid this by generating additional mutations such as deletion of tumor suppressors.