14-OR

Abstract

Objectives To determine whether cardiac morphofunctional modifications and plasma concentrations of BNP, differentiate women with early-onset preeclampsia (EOPE) from late-onset preeclampsia (LOPE) and to identify correlation between the morphological heart modifications and BNP in the groups analyzed. Methods A prospective cross-sectional study was performed with 85 pregnant women, classified into three groups: EOPE ( n = 30), LOPE (⩾34 weeks, n = 32) and NT (normotensive pregnant women, n = 23). Pregnant women underwent echocardiography and BNP plasma measurement by the time of the PE diagnosis. The results were analyzed by using the Kruskal–Wallis test followed by Dunn’s multiple comparisons, and correlations were tested using Spearman correlation with a significance level set at 5%. Results PE was associated with an increased left ventricular mass index, regardless of gestational age. However, in the EOPE group, the LV relative thickness (RT) was significantly higher than in the LOPE, thus allowing association of EOPE with a concentric pattern of hypertrophy, and this was present in 40% of women in the EOPE, 15.6% of the LOPE and in the NT group there was no change in LV geometry. Diastolic dysfunction was observed in 23% of women in the EOPE group and in 15.6% of the LOPE group, a significant difference occurring only between EOPE and NT groups. BNP values were higher for the EOPE (214 pg/mL), followed by the LOPE (147 pg/mL), when compared with the NT group (43 pg/mL). In pregnant women with PE, BNP was significantly correlated with RT and with LVMi. Conclusions The early-onset PE has a greater impact on the heart, increasing the risk of concentric hypertrophy and diastolic dysfunction compared with LOPE. These findings may determine the therapeutic choice and identify patients in need for future cardiovascular follow-up. Disclosures V.T. Borges: None. S. Zanati: None. M.T. Peracoli: None. I.C. Weel: None. J.R. Poiati: None. M.L. Matias: None. J.C. Peracoli: None.