Abstract
14C-Labeling of the New Antiasthmatic Flezelastine Flezelastine is a new phthalazinone derivative with antiasthmatic/antiallergic activity. For pharmacokinetic studies 14C-labeled flezelastine was synthesized starting with [7,8-14C]-phthalic anhydride. In a convergent synthesis 1.5 g of double 14C-labeled flezelastine hydrochloride (ASTA code: D–18024) with a specific activity of 3 MBq/mg was obtained.
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