Abstract
CF have rarely been studied in chronically uremic children. Six children on H were evaluated with 16 neuropsychologic tests pre, 12 and 24 hrs post dialysis. There were 5 boys and I girl II to 18 yrs old with duration of uremia 6 to 52 months. Mean pre-dialysis creatinine at the time of testing was 9.2mg% and the mean change post dialysis was -6.4 ± 2.1 mg%. Results, utilizing a Friedman two-way analysis of variance, revealed that 6/16 measures changed significantly and the Walsh test showed differences between each of the three time periods. + = improved, O = no change Similar changes were not observed in 6 age and sex matched normal children. The results indicate that uremia adversely affects selective higher cortical brain functions in children. The speed of central processing, particularly when coordination of visual and motor acts is required, is best at 24 hrs and least pre-dialysis. Attention and memory were more compromised at 12 hrs than at 24 hrs, despite increasing uremia,suggesting that rapid volume and/or electrolyte shifts contribute to decreased performance.
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