149-LB: Fasting Blood Glucose (FBG) and Cardiovascular Disease (CVD) Risk in Hispanic Youth with Obesity

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Introduction: Youth of minority race-ethnicity have higher prevalence of obesity and are at increase in risk for comorbidities. Elevated FBG within the normal range has been related to a decline in beta cell function. The relationship of FBG to CVD risk in youth is not clear. We investigated the relationship between FBG and CVD risk factors in a cohort of Hispanic youth with overweight (OW) and obesity (OB).Methods: 372 (186 males) pubertal, nondiabetic adolescents; mean age (SD) 13.9±2.5 years; 26% OW and 74% OB. They underwent measurement of anthropometrics, blood pressure (BP); body composition; fasting glucose, insulin, CRP, ALT, AST, triglycerides (TG), total, LDL and HDL-cholesterol. The homeostasis model assessment of insulin resistance (HOMA-IR) and TG to HDL ratio were calculated. Subjects were compared across tertiles of FBG (general linear model adjusting for sex).Results: The three FBG tertiles didn’t differ with respect to age, Tanner stage, %body fat, truncal fat, or liver transaminases. Measures of insulin resistance (IR), inflammation, dyslipidemia and BP increased across tertiles of FBG (Table 1).Conclusion: Elevated FBG in the nondiabetic range is associated with greater degree of IR, inflammation and adverse CVD risk profile, independent of total body or truncal fat or evidence of fatty liver disease. This data suggest that higher FBG identifies obese Hispanic youth at high risk for CVD.View largeDownload slideView largeDownload slide DisclosureR. S. Shawar: None. M. R. Puyau: None. F. Bacha: None.