149: INCIDENCE, PREVALENCE, AND ASSOCIATION OF VASCULAR DISORDERS AMONG TAKAYASU ARTERITIS

Abstract

Introduction: Studies have shown that patients with systemic vasculitis such as takayasu arteritis (TA) experience a higher incidence of hypertension, primary myocardial infarction (MI), and other vascular disorders. The aim of our study is to assess the incidence, prevalence, and association of vascular disorders amongst TA in the US population. Methods: We performed a cross-sectional retrospective study of the NIS database (2016-2018) using the ICD-10-CM codes. Hospitalizations with a diagnosis of TA and other comorbidities were identified. Weighted univariate analysis was performed using an unpaired t-test and chi-square test and multivariate analysis were performed using multivariate regression models to evaluate incidence, prevalence, and association of vascular disorders among TA. Results: We found 3,560 patients with TA. The incidence of MI (3.09% vs 2.15%), transient ischemic attack (1.4% vs 0.36%), and intracerebral hemorrhage (0.56% vs 0.24%) were higher in TA compared to no TA. (p <.0001) Concurrent prevalence of hypertension (67.7% vs 55.72%), dyslipidemia (35.96% vs 32.42%), ischemic heart disease (32.3% vs 22.21%), and congestive heart failure (23.17% vs 16.15%) higher amongst TA in comparison without TA. (p <.0001) In regression analysis, we found that patients with hypertension (aOR 4.49, 95%CI 3.26-6.19), dyslipidemia (1.34, 1.10-1.63), renal failure (1.30, 1.04-1.62), congestive heart failure (1.95, 1.56-2.45), MI (1.63, 1.16-2.27), angina (2.72, 1.01-7.32), acute ischemic stroke (1.86, 1.25-2.77), transient ischemic stroke (5.06, 3.09-8.28), subarachnoid hemorrhage (2.84, 1.17-6.93) (c=0.501) had significantly higher odds of takayasu’s arteritis. Conclusions: In our data, we identified a higher incidence, prevalence, and association of some vascular events amongst TA. Hence, more prospective studies are needed to evaluate the early identification to reduce the burden of vascular events amongst TA populations. Our study is confounded by the absence of severity and outcomes of disease, causality, and long-term follow-up of the patients.