1488 Melanoma cell-of-origin PDL1 promotes early tumor progression and distinct immune outcomes in a novel autochthonous NRAS-mutant melanoma model

Abstract

BackgroundTumor-intrinsic PDL1 signals are drivers of treatment resistance in distinct aggressive tumors, such as melanoma.1–3 Melanocytes, the melanoma cell-of-origin do not express PDL1 at baseline but exhibit a stepwise progression...