Abstract
Previous studies showed that TP inhibits tissue heme oxygenase activity (HO) and lowers serum total bilirubin levels [B], but does not effect the VeCO of neonatal rats with and without artificially created hematomas (H). It is possible that intestinal bacteria play a role in this model by metabolizing excreted heme to CO. Rat litters, with intestines sterilized by antibiotics, were divided into 3 groups of 3 rats each. At 12 h postpartum (t=0), the TP/H rats were injected with TP (65 μmoles/kg). Hematomas were given to H and TP/H rats (t=45 h). Rats were sacrificed at t=113 h. The [B] of the TP/H rats was not reduced, but hepatic HO activity was suppressed (p < .005) when compared to the H control group. The overall average VeCO of H rats was increased by ∼ 45% over S rats and TP was effective in delaying and suppressing this increase; the inhibition of average VeCO was ∼ 25%. The results suggest that in antibiotic-treated rats with artificial hematomas: 1) single dose TP was effective in lowering VeCO and thus total bilirubin formation and 2) intestinal bacteria may contribute significantly to VeCO, if endogenous heme degradation is inhibited.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
