1485-P: Difference between Comprehensive Physical Fitness Age and Calendar Age Is a Potent Predictor of Incident Metabolic Syndrome (MetS)

Abstract

Although grip strength, single-leg balance and trunk flexibility each are reportedly predictive of type 2 diabetes and atherosclerosis, little is known about the impact of comprehensive physical fitness adjusted by age on these cardiovascular risks. Thus, we developed a new index of comprehensive physical fitness standardized by age (e.g., the physical fitness index (PFI)) and examined its relevance to incident MetS in Japanese. Analyzed were 8,041 non-MetS persons (5291 men) aged 22 to 86 y who underwent the physical fitness tests cited above yearly for 4 y. MetS was defined according to Japanese guidelines. Participants were stratified yearly by sex and age (≤39, 40-49, 50-59, 60-69, 70≤), and an equation was developed using the above 3 tests by principal component analysis. We defined PFI as the difference between physical fitness age and calendar age. Discrete-time logit models were used to examine the influence of PFI on the incidence of MetS. MetS occurred in 355 persons. PFI was negatively correlated with MetS incidence. In multivariate analysis, comparison of the high PFI group with the moderate and low PFI groups showed a 1.38 (95% CI 1.01-1.88) fold and 1.98 fold (1.45-2.71) increased risk, respectively. The PFI could be used as a non-invasive and simple screening tool for those at high cardiometabolic risk, which is independent of calendar age in a Japanese population. Disclosure T. Sato: None. K. Fujihara: None. M.H. Yamada: None. Y. Yaguchi: None. M. Kitazawa: None. Y. Matsubayashi: None. M. Iwanaga: None. T. Yamada: None. K. Kato: None. H. Sone: Research Support; Self; Kyowa Hakko Kirin Co., Ltd., Novartis AG, Ono Pharmaceutical Co., Ltd., Taisho Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co.