1484-P: CD57+CD8+T Cells Exhibit Distinct Features in T1D Patients with Partial Remission Phase

Abstract

Partial remission (PR) in type 1 diabetes (T1D) is accompanied by downregulation of the immune response. The CD8+ CD57+ T cells, termed effector memory cells, is expanded in several immune-mediated diseases, but their changes in the PR phase are unclear. Combined with flow cytometry and bioinformatics analysis, we found that CD8+ CD57+ T cells had strong cytotoxic functions and transcriptional heterogeneity, and that the proportion of CD8+ CD57+ T cells increased in new-onset patients, decreased in patients during PR and then repleted again after the end of PR. These findings suggests that CD8+ CD57+ T cells might have potential roles in immune modulation during the PR stage and might serve as a therapeutic target. Disclosure X.Li: None. T.Zhong: None. R.Tang: None. X.Li: None. L.Kang: None.