Abstract

Papillary Renal Cell Carcinoma (pRCC) is the most common non-clear cell RCC (nccRCC). In silico, we identified 4 subgroups according to the proportion of immune and stromal cell populations in a preliminary study in 271 localized pRCC tumors using RNA-seq data from The Cancer Genome Atlas (TCGA), validated in independent cohort. Thus, the microenvironment of pRCC is yet to be described in a cohort of metastatic pRCC treated with systemic therapy and its association with response and outcomes to be assessed.

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