Abstract
Introduction: Mesenchymal stem cells (MSCs) have been shown to exert important immunomodulatory effects in both acute and chronic diseases. However, in acute inflammatory conditions, like septic shock, immunomodulatory cell therapy must be administered within hours of diagnosis. While “off-the-shelf” cryopreserved allogeneic cell products are best suited for sepsis therapy, the immunomodulatory potency of freshly thawed cells injected immediately has not been well documented. In this study, we compared the abilities of “freshly cultured” versus “freshly thawed” MSCs in modulating immune responses.
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