Abstract
Background: Melanoma eludes immunologic destruction, in part, through induction of immunosuppressive regulatory T cells (Tregs). Thrombospondin-1 (TSP-1) is an inducible matricellular protein with roles in cell-adhesion, migration and inflammation and has recently been found to generate Tregs. We hypothesized that melanoma induces Tregs through secreted TSP-1. Methods: Melanoma-conditioned media (MCM) was generated from cell-free supernatant from a metastatic melanoma cell line (A375) and was probed for TSP-1 by Western blot.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
