Abstract
Primary cutaneous CD4+ small /medium T-cell lymphoproliferative disorder (PC-SMTLD) has recently been considered as a distinct clinicopathological entity. Because of a considerable degree of overlap with pseudolymphoma, diagnosis of PC-SMTLD is often challenging. The methylation of DNA at position 5 of cytosine, and the subsequent reduction in intracellular 5-hydroxymethylcytosine (5-hmC) levels, is a key epigenetic event in several cancers, including systemic lymphomas. However, this epigenetic marker has never been studied in cutaneous lymphomas.
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