Abstract
To determine the reliability of 2-dimensional, pulsed Doppler (2D-PD) ultrasonography as a bedside technique for measuring changes in brain blood flow and cardiac output we used a 2D-PD mechanical sector scanner to measure: ascending aortic diameter and flow velocity and peak and trough frequency shifts (f) in a basal cerebral artery (BCA) through an artificial fontanel in 6 newborn lambs during hemorrhage (25cc/kg) and dopamine infusion (5 and 20 μg/kg/min). We calculated cardiac output, BCA pulsatility index (PI) and BCA mean frequency and compared measurements by linear regression analysis to cardiac output and brain blood flow determined by the radioactive microsphere technique. Summary of results: (N = 24 determinations) Peak, trough and mean frequency measurements from a basal cerebral artery and 2D-PD measurements of cardiac output paralleled changes in brain blood flow and cardiac output determined with microspheres. Pulsatility index did not. We conclude that 2D-PD can be used to quantitate changes in brain blood flow and cardiac output.
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