Abstract
Osteoradionecrosis (ORN) is a long-term and debilitating complication related to radiotherapy-based treatment for head and neck cancer (HNC). With no universal consensus on an optimal treatment regime, ORN management remains challenging. Treatment for advanced or refractory ORN has historically been limited to surgical resection and reconstruction. The fibroatrophic hypothesis for the aetiopathogenesis of ORN led to administration of pentoxifylline, tocopherol and clodronate (PENTOCLO) in the management of ORN.
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