1438 Stromal hypersialylation within colorectal tumors contributes to immunosuppression of T cell adaptive immunity in the tumor microenvironment

Abstract

BackgroundThe tumor microenvironment (TME) is abundant in cancer-associated fibroblasts (CAFs) that radically influence the cancer disease trajectory, especially in colorectal cancers (CRC). Directly targeting cancer-associated fibroblasts may hold great promise...