Abstract
In order to test the hypothesis that treatment with IV indomethacin to close the ductus arteriosus has beneficial effects on lung function in preterm infants with HMD, 9 preterm infants requiring ventilator support on day 3(mean birthweight 1186±276 gm, gestational age 29±3 wk)were given 0.2mg/kg of indomethacin IV on day 3-4 of life. They were compared with 16 concurrent random controls with HMD on ventilators on day 3(birthweight 1063±282 g, gestational age 28±2 wk) who did not receive indomethacin. The observed differences between treatment and control groups on day 3, and within groups (day 3 vs. day 5) are not statistically significant (p >.05). These data suggest that although IV indomethacin may significantly alter the patency of the ductus arteriosus, administration of this drug on day 3-4 of life is not associated with a significant improvement in preterm infants with HMD.
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