143-POS

Abstract

Objectives Adipose tissue is responsible for triggering systemic inflammatory response and these changes may be involved in the pathophysiology of preeclampsia. To characterize the lipid profile in the placenta of patients with early-onset preeclampsia. Methods Samples were collected from placenta of 10 pregnant women with early-onset preeclampsia and 10 controls. Lipids were extracted using the Bligh-Dyer protocol and were analyzed by MALDI TOF–TOF mass spectrometry. Results The placental analysis of patients with preeclampsia revealed the main class glycerophosphoserines-GP03 (PS) as the most prevalent lipid, representing 56.28% of the total composition. Other main class found was macrolides/lactone polyketides-PK04 with 32.77%, both were increased in preeclamptic placentas when compared to the control group, PS (p Conclusions Placental tissues from patients with preeclampsia expressed different lipid profile when compared to normal pregnant women. These findings suggest that specific lipidic species may be more associated with risk of developing preeclampsia than others. Interestingly, some of the lipids identified here have important cell functions that may be involved in the pathophysiology of preeclampsia. Disclosures H.A. Korkes: None. N. Sass: None. A.F. Moron: None. N.O. Câmara: None. T. Bonetti: None. A.S. Cerdeira: None. I.D. Silva: None. L.G. De Oliveira: None.