143 AUGMENTATION INDEX IN RADIAL ARTERY AS CENTRAL HEMODYNAMIC INDEX IS INDEPENDENT VARIABLE FOR AORTIC CALCIFICATION

Abstract

Background: The aim of this study was to elucidate whether coronary artery and aortic calcification is associated with central hemodynamic indexes. Methods: The subjects consisted of 105 patients with suspected coronary artery disease who underwent multi-detector row computed tomography. Calcification of thoracic aorta and coronary artery was evaluated by the method of Agatston. Central hemodynamic indexes including central blood pressure (CBP), augmentation index in radial artery (AIx) were measured by radial artery tonometry. Results: The patients with aortic calcification (65%) and patients without it (35%) were analysed by univariate analysis. Patients with aortic calcification were older (p<0.001), had higher pulse pressure (p=0.006), higher AIx (p<0.001), and bigger brachial-ankle pulse wave velocity (PWV) (p=0.002). In a multivariate logistic regression analysis, age (odds ratio(OR):14.8, 95% confidence interval(CI) 0.05–0.17) and AIx (OR:4.2, 95%CI 0.01–0.09) were significant independent variables for aortic calcification. Next, patients with coronary artery calcification (47%) and patients without it (53%) were analysed by univariate analysis. Patients with coronary artery calcification were older (p<0.001), had higher prevalence of hypertension (p=0.01), lower brachial diastolic pressure (p=0.02), and bigger PWV (p=0.03). In a multivariate analysis, prevalence of hypertension (OR:4.2, 95%CI 0.02–0.91) and brachial diastolic pressure (OR:4.8, 95%CI 0.004–0.09) were significant independent variables for coronary artery calcification. Conclusions: AIx as central hemodynamic index was independent variable for aortic calcification. In this study, coronary artery calcification was not associated with central hemodynamic indexes. These data may indicate that patients with high central hemodynamic indexes have aortic stiffness rather than coronary arterial stiffness.