Abstract
Head and neck cancer (HNC) diagnosis could trigger post-traumatic stress disorder (PTSD). In addition, adverse childhood experiences (ACEs), depression, and individual differences in cortisol levels could influence the vulnerability to PTSD in cancer patients. Single nucleotide variants (SNVs) on genes of the hypothalamic-pituitary-adrenal axis, involved in stress response, such as CRHR1 (rs110402, C/T), FKBP5 (rs3800373, G/T), and NR3C1 (rs41423247, C/G), may impact cortisol production. However, the influence of psychosocial and genetic factors on HNC-related PTSD is not fully known.
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