1426 HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITY AND AUTONOMIC NERVOUS SYSTEM CHANGES IN PATIENTS WITH CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME COMPLICATED BY ERECTILE DYSFUNCTION

Abstract

You have accessJournal of UrologyInfections/Inflammation of the Genitourinary Tract: Prostate & Genitalia1 Apr 20111426 HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITY AND AUTONOMIC NERVOUS SYSTEM CHANGES IN PATIENTS WITH CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME COMPLICATED BY ERECTILE DYSFUNCTION Jian Bai, Jihong Liu, Shaogang Wang, Li Zhuan, Deng He, Min Ni, and Zhangqun Ye Jian BaiJian Bai Wuhan, China, People's Republic of More articles by this author , Jihong LiuJihong Liu Wuhan, China, People's Republic of More articles by this author , Shaogang WangShaogang Wang Wuhan, China, People's Republic of More articles by this author , Li ZhuanLi Zhuan Wuhan, China, People's Republic of More articles by this author , Deng HeDeng He Wuhan, China, People's Republic of More articles by this author , Min NiMin Ni Wuhan, China, People's Republic of More articles by this author , and Zhangqun YeZhangqun Ye Wuhan, China, People's Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1338AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS) have been known to be reactive to psychological factors such as stress. Growing data suggest that stress conditions could be associated with the development or aggravation of prostatic disease. The present study aims to investigate the characteristics of ANS and HPA axis in Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) concomitant with and erectile dysfunction (ED). METHODS We recruited 25 CP/CPPS men with ED (group 1), 25 CP/CPPS men with voiding symptom only (group 2), 25 men with ED no CP/CPPS (group 3) and 25 age-matched, asymptomatic controls (group 4). Saliva samples were collected on 2 consecutive days at 9 specific times with strict reference to time of morning awakening for evaluation of free cortisol, reflecting secretory activity of the HPA axis. We quantified cortisol variations as the 2-day average slope of the awakening cortisol response and the subsequent diurnal levels. Heart rate variability (HRV) analysis was performed using the 24 hour Holter monitorisation. RESULTS One-way ANOVA showed that HRV values in patients from the four groups are similar. Mean ratio of LF/HF in groups 1 was 2.28¡À1.96, more higher compared with group 4 (1.24¡À0.62, P=0.015). However, HPA axis measures were not changed significantly. CONCLUSIONS The HRV changes suggest altered autonomic nervous system responses in men with CP/CPPS and ED. Predominance of sympathetic nervous system activity is possibly associated with comitant CP/CPPS and ED, whereas HPA axis activity is not. Observations suggest opportunities for neurophysiological study of relationships of stress, ED and CP/CPPS. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e571 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jian Bai Wuhan, China, People's Republic of More articles by this author Jihong Liu Wuhan, China, People's Republic of More articles by this author Shaogang Wang Wuhan, China, People's Republic of More articles by this author Li Zhuan Wuhan, China, People's Republic of More articles by this author Deng He Wuhan, China, People's Republic of More articles by this author Min Ni Wuhan, China, People's Republic of More articles by this author Zhangqun Ye Wuhan, China, People's Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...