142-POS

Abstract

Objectives This study aimed to assess whether pregnancy induced hypertension (PIH) affects the risk of cardiovascular disease (CVD) in later life in Japanese women. Methods The eligible study population consisted of 1100 women who were ⩾ 40 years old, underwent a health check-up at a periodic health examination facility in Aichi, Japan, between January 2012 and December 2013, and had experience giving birth. Questionnaires were sent to potential participants and they were encouraged to provide their Maternal and Child Health Handbooks. We recruited women with a history of PIH (PIH group) and women with uncomplicated pregnancies (control group). Information was obtained from the Maternal and Child Health Handbooks. We assessed the association between history of PIH and risk of CVD such as hypertension, diabetes mellitus, and dyslipidemia in later life. Results Antihypertensive medication use rate was higher in PIH group compared to those without PIH. With respect to risk factors for CVD, triglycerides were significantly higher, while HDL-cholesterol was significantly lower in the PIH group compared to control group. The PIH group showed a significantly higher proportion of dyslipidemic medication use after menopause. Conclusions Our findings suggest that Japanese women with a history of PIH may have an increased risk of hypertension and dyslipidemia in later life. Disclosures K. Watanabe: None. C. Kimura: None. A. Iwasaki: None. T. Mori: None. H. Matsushita: None. K. Shinohara: None. A. Wakatsuki: None.