Abstract
Background: SALL2 is a developmental transcription factor involved in the regulation of cell proliferation, migration, and survival. Massive data analyses of cancer versus normal tissues indicate that SALL2 mRNA is significantly decreased in colorectal cancer (CRC), a cancer type characterized by hyperactivation of the Wnt pathway. Interestingly, our previous ChIP-seq analyses suggested that SALL2 regulates genes associated with the Wnt pathway, including the negative regulator AXIN2. Currently, SALL2 function and its relationship with the Wnt/β-catenin pathway in colorectal cancer is unknown.
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