Abstract
Background: SALL2 is a developmental transcription factor involved in the regulation of cell proliferation, migration, and survival. Massive data analyses of cancer versus normal tissues indicate that SALL2 mRNA is significantly decreased in colorectal cancer (CRC), a cancer type characterized by hyperactivation of the Wnt pathway. Interestingly, our previous ChIP-seq analyses suggested that SALL2 regulates genes associated with the Wnt pathway, including the negative regulator AXIN2. Currently, SALL2 function and its relationship with the Wnt/β-catenin pathway in colorectal cancer is unknown.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
