Abstract
Breast cancer (BC) is the most frequent malignancy in Ukrainian women. Among the growing number of cases, hereditary BC comprises 5-15% of cases worldwide. Inheritance of genetic alterations is approximated to underlie 5-10% of BC occurrences and is a major point of concern regarding women's health. Despite the existence of national screening for BC in Ukraine, little is known about the rate and genetic causes of hereditary BC in the Ukrainian population. The goal of the study was to assess the spectrum of germline mutations in patients with BC with respect to the molecular subtypes.
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