141 - The Effects of Timing in Measurement of Pulmonary Artery Diastolic Pressure with CardioMEMS Hemodynamic Monitoring

Abstract

Background: CardioMEMS wirelessly measure the pulmonary artery diastolic pressure (PAdP) and has been shown to reduce heart failure (HF) related hospitalization. PAdP is usually measured in the morning. We observed variation in PAdP in the morning and afternoon after medication use. The aim of our research was to study difference in morning and afternoon PAdP with medication use. Methods: We collected one month data of 15 HF patients managed with CardioMEMS device. PAdP was measured in the morning prior to medication use and in the afternoon (3 to 5 hours after the medication use), and then we compared the mean values. The data were examined using a mixed linear model approach. Results: The data on patient characteristics and medications used are depicted on Table 1. The mean morning PAdP was 23.16 mmHg and PAdP in the afternoon was 20.84 mmHg which is 10% lower than the morning PAdP. This difference is statistically significant with P value <.001. Conclusion: The significant decrease in the PAdP is observed during afternoon measurement compared to morning measurement. This may demonstrate the efficacy of medications, and suggest that the use of PAdP monitoring after the medication administration in afternoon instead of morning pressure monitoring may reflect better PAdP status. However, these will need more studies to establish utility, and to evaluate the outcome on HF rehospitalization in the future.